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Fabgennix

TRF2 Polyclonal Antibody

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TRF2 Polyclonal Antibody

Product Details

TRF2-212AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Telomeric repeat-binding factor 2 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Telomeric DNA-binding protein; telomeric protein; telomeric repeat binding protein 2; Telomeric repeat-binding factor 2; TTAGGG repeat-binding factor 2

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Gene Aliases: TERF2; TRBF2; TRF2

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UniProt ID: (Human) Q15554, (Mouse) O35144

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Entrez Gene ID: (Human) 7014, (Rat) 361403, (Mouse) 21750

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Function(s)
DNA binding double-stranded telomeric DNA binding telomerase activity protein binding enzyme binding telomeric DNA binding protein homodimerization activity macromolecular complex binding G-rich strand telomeric DNA binding chromatin binding protein C-terminus binding
Process(es)
telomere maintenance in utero embryonic development positive regulation of gene expression negative regulation of gene expression obsolete telomere maintenance via telomere shortening telomere capping telomeric loop formation protection from non-homologous end joining at telomere negative regulation of telomere maintenance positive regulation of telomere maintenance positive regulation of nitric-oxide synthase activity protein localization to chromosome, telomeric region negative regulation of beta-galactosidase activity negative regulation of cellular senescence cell cycle regulation of telomere maintenance RNA-dependent DNA biosynthetic process negative regulation of telomere maintenance via recombination regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via telomerase negative regulation of telomere maintenance via semi-conservative replication telomeric D-loop disassembly cellular senescence axonal transport of messenger ribonucleoprotein complex negative regulation of telomere single strand break repair negative regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening negative regulation of t-circle formation negative regulation of telomeric D-loop disassembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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