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Invitrogen
TRIB2 Polyclonal Antibody
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FIGURE: 1 / 4
TRIB2 Antibody (PA5-80186) in IHC (P)
Immunohistochemistry analysis of TRIB2 on paraffin-embedded human tonsil tissue. Sample was incubated with TRIB2 polyclonal antibody (Product# PA5-80186) with a dilution of 1 µg/mL, and developed by Streptavidin-Biotin-Complex (SABC) with DAB chromogen method.
Product Details
PA5-80186
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human TRIB2 (175-211aa DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSD).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: SW620 whole cell. IHC: mouse spleen tissue, rat spleen tissue, human tonsil tissue.
Target Information
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ser/thr kinase; TRB-2; trib2; TRIB2 (HGNC:30809); Tribbles homolog 2; unnamed protein product
Gene Aliases: AW319517; C5FW; GS3955; RGD1564451; TRB-2; TRB2; TRIB2
UniProt ID: (Human) Q92519, (Mouse) Q8K4K3
Entrez Gene ID: (Human) 28951, (Rat) 313974, (Mouse) 217410
nucleotide binding
protein kinase activity
protein kinase inhibitor activity
protein binding
mitogen-activated protein kinase kinase binding
ubiquitin protein ligase binding
ubiquitin-protein transferase regulator activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
ATP binding
transcription factor binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of interleukin-10 production
regulation of MAP kinase activity
negative regulation of fat cell differentiation
negative regulation of interleukin-10 biosynthetic process
regulation of catalytic activity
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of ubiquitin-protein transferase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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