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Fabgennix
TRIF Polyclonal Antibody
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Product Details
TRIF-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 150-199 on human E3 ubiquitin-protein ligase RNF138 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hCG_39321; HSD34; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; RNF36; TI; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1
Gene Aliases: AW046014; AW547018; IIAE6; MyD88-3; PRVTIRB; TICAM-1; TICAM1; TRIF
UniProt ID: (Human) Q8IUC6, (Mouse) Q80UF7
Entrez Gene ID: (Human) 148022, (Mouse) 106759, (Rat) 363328
macrophage activation involved in immune response
MyD88-independent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of B cell proliferation
positive regulation of protein ubiquitination
lipopolysaccharide-mediated signaling pathway
positive regulation of protein binding
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of natural killer cell activation
negative regulation of MyD88-independent toll-like receptor signaling pathway
TRIF-dependent toll-like receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
regulation of protein homodimerization activity
positive regulation of chemokine biosynthetic process
innate immune response
positive regulation of interferon-beta biosynthetic process
positive regulation of nitric oxide biosynthetic process
positive regulation of NF-kappaB transcription factor activity
defense response to virus
necroptotic process
apoptotic signaling pathway
immune system process
apoptotic process
signal transduction
positive regulation of type I interferon production
response to lipopolysaccharide
positive regulation of B cell activation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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