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Fabgennix

TRIF Polyclonal Antibody

View all (16) TRIF antibodies

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TRIF Polyclonal Antibody

Product Details

TRIF-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 150-199 on human E3 ubiquitin-protein ligase RNF138 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: hCG_39321; HSD34; MyD88-3; Proline-rich, vinculin and TIR domain-containing protein B; Putative NF-kappa-B-activating protein 502H; RNF36; TI; TICAM-1; TIR domain containing adaptor inducing interferon-beta; TIR domain-containing adapter molecule 1; TIR domain-containing adapter protein inducing IFN-beta; TIR domain-containing adaptor inducing interferon-beta; toll like receptor adaptor molecule 1; toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; toll-like receptor adaptor molecule 1

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Gene Aliases: AW046014; AW547018; IIAE6; MyD88-3; PRVTIRB; TICAM-1; TICAM1; TRIF

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UniProt ID: (Human) Q8IUC6, (Mouse) Q80UF7

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Entrez Gene ID: (Human) 148022, (Mouse) 106759, (Rat) 363328

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Function(s)
protein binding protein kinase binding signaling adaptor activity binding, bridging signal transducer activity scaffold/adaptor protein
Process(es)
toll-like receptor signaling pathway macrophage activation involved in immune response immune system process positive regulation of myeloid dendritic cell cytokine production MyD88-independent toll-like receptor signaling pathway nitric oxide biosynthetic process apoptotic process inflammatory response signal transduction cell surface receptor signaling pathway positive regulation of autophagy positive regulation of gene expression positive regulation of B cell proliferation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway TRIF-dependent toll-like receptor signaling pathway B cell proliferation B cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly response to exogenous dsRNA innate immune response positive regulation of nitric oxide biosynthetic process positive regulation of B cell activation defense response to virus positive regulation of macrophage cytokine production cellular response to lipopolysaccharide apoptotic signaling pathway cellular response to oxidised low-density lipoprotein particle stimulus positive regulation of cytokine production involved in inflammatory response positive regulation of protein binding regulation of protein homodimerization activity positive regulation of chemokine biosynthetic process positive regulation of interferon-beta biosynthetic process positive regulation of NF-kappaB transcription factor activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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