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Invitrogen

TRIM21 Polyclonal Antibody

View all (28) TRIM21 antibodies

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TRIM21 Polyclonal Antibody

Product Details

PA5-106903

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TRIM21(Accession P19474), corresponding to amino acid residues P444-Y475.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2854567

Product Specific Information

Antibody detects endogenous levels of total TRIM21.

Target Information

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; 52-kD Ro/SSA ribonucleoprotein; 52kD Ro/SSA autoantigen; 52kDa ribonucleoprotein autoantigen SS-A/Ro; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Ro/SSA 52kDa; Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SS-A; tripartite motif protein 21; Tripartite motif-containing protein 21

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Gene Aliases: RNF81; Ro/SSA; RO52; SSA; SSA1; TRIM21

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UniProt ID: (Human) P19474

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Entrez Gene ID: (Human) 6737, (Rat) 308901, (Mouse) 20821

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Function(s)
DNA binding transcription coactivator activity RNA binding ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity identical protein binding metal ion binding ubiquitin protein ligase activity UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity ubiquitin-protein ligase
Process(es)
autophagosome assembly protein polyubiquitination protein monoubiquitination I-kappaB kinase/NF-kappaB signaling regulation of gene expression proteasomal protein catabolic process positive regulation of autophagy protein ubiquitination protein destabilization negative regulation of NF-kappaB transcription factor activity positive regulation of protein binding regulation of type I interferon production negative regulation of viral transcription stress granule assembly response to interferon-gamma stress granule disassembly protein K27-linked ubiquitination negative regulation by host of viral release from host cell innate immune response positive regulation of cell cycle negative regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell protein autoubiquitination cellular response to chemical stress pyroptosis protein K63-linked ubiquitination protein K48-linked ubiquitination regulation of primary metabolic process protein K6-linked ubiquitination negative regulation of protein deubiquitination antiviral innate immune response positive regulation of NIK/NF-kappaB signaling positive regulation of sequence-specific DNA binding transcription factor activity protein trimerization negative regulation of viral release from host cell cell cycle
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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