Sequence of this protein is as follows: SQEAREGTQG ERCAVHGERL HLFCEKDGKA LCWVCAQSRK HRDHAMVPLE EAAQEYQEKL QVALGELRRK QELAEKLEVE IAIKRADWKK TVETQKSRIH AEFVQQKNFL VEEEQRQLQE LEKDEREQLR ILGEKEAKLA QQSQALQELI SELDRRCHSS ALELLQEVII VLERSESWNL KDLDITSPEL RSVCHVPGLK KMLRTCAVHI TLDPDTANPW LILSEDRRQV RLGDTQQSIP GNEERFDSYP M
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
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Protein Aliases: 52 kDa ribonucleoprotein autoantigen Ro/SS-A; 52 kDa Ro protein; E3 ubiquitin-protein ligase TRIM21; RING finger protein 81; RING-type E3 ubiquitin transferase TRIM21; Ro(SS-A); Sicca syndrome antigen A; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SS-A; tripartite motif-containing 21; Tripartite motif-containing protein 21
Gene Aliases: RNF81; Ro/SSA; RO52; SSA; SSA1; TRIM21
UniProt ID: (Human) P19474
Entrez Gene ID: (Human) 6737
Molecular Function: ubiquitin-protein ligase