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Proteintech
TRPC6 Polyclonal Antibody
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Product Details
18236-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRPC6 Fusion Protein Ag12976 (1-405 aa encoded by BC093658)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSQSPAFGP RRGSSPRGAA GAAARRNESQ DYLLMDSELG EDGCPQAPLP CYGYYPCFRG SDNRLAHRRQ TVLREKGRRL ANRGPAYMFS DRSTSLSIEE ERFLDAAEYG NIPVVRKMLE ECHSLNVNCV DYMGQNALQL AVANEHLEIT ELLLKKENLS RVGDALLLAI SKGYVRIVEA ILSHPAFAEG KRLATSPSQS ELQQDDFYAY DEDGTRFSHD VTPIILAAHC QEYEIVHTLL RKGARIERPH DYFCKCNDCN QKQKHDSFSH SRSRINAYKG LASPAYLSLS SEDPVMTALE LSNELAVLAN IEKEFKNDYK KLSMQCKDFV VGLLDLCRNT EEVEAILNGD VETLQSGDHG RPNLSRLKLA IKYEVKKFVA HPNCQQQLLS IWYENLSGLR QQTMAV (1-405 aa encoded by B C093658)
Target Information
Trpc6 forms a receptor-activated calcium channel in the cell membrane. The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the 'canonical TRP' (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel. Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo. Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; HGNC:12338; Short transient receptor potential channel 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6; trp6A; TrpC6
Gene Aliases: AV025995; FSGS2; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; TRP-6; TRP6; TRPC6; Trrp6
UniProt ID: (Human) Q9NQA9, (Mouse) Q61143
Entrez Gene ID: (Human) 7225, (Mouse) 22068
cation transport
manganese ion transport
positive regulation of cytosolic calcium ion concentration
single fertilization
aging
positive regulation of peptidyl-threonine phosphorylation
platelet activation
neuron differentiation
positive regulation of ion transmembrane transporter activity
positive regulation of neuron differentiation
negative regulation of dendrite morphogenesis
regulation of cytosolic calcium ion concentration
positive regulation of calcium ion transport
cellular response to hydrogen peroxide
calcium ion transmembrane transport
cellular response to hypoxia
transport
ion transport
calcium ion transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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