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Bioss
TRPM4 Polyclonal Antibody
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FIGURE: 1 / 1
TRPM4 Antibody (BS-9051R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse brain; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with TRPM4 Polyclonal Antibody, Unconjugated (bs-9051R) at 1:500 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DA... View More
Product Details
BS-9051R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TRPM4, amino acids 800-850.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. Mediates transport of monovalent cations (Na+, K+, Cs+, Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-activated non-selective cation channel 1; H LTrpC-4; hTRPM4; Long transient receptor potential channel 4; LTrpC-4; LTrpC4; melastatin like 2 protein; Melastatin-4; Melastatin-like 2; MLS2s; Transient receptor potential cation channel subfamily M member 4; transient receptor potential cation channel, subfamily M, member 4; transient receptor potential ion channel melastatin subgroup member 4
Gene Aliases: 1110030C19Rik; AW047689; hTRPM4; LTrpC-4; LTRPC4; Mls2s; PFHB1B; TRPM4; TRPM4B
UniProt ID: (Human) Q8TD43, (Mouse) Q7TN37, (Rat) Q9ESQ5
Entrez Gene ID: (Human) 54795, (Mouse) 68667, (Rat) 171143
adaptive immune response
dendritic cell chemotaxis
regulation of T cell cytokine production
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
positive regulation of heart rate
protein sumoylation
negative regulation of bone mineralization
sodium ion transmembrane transport
positive regulation of insulin secretion involved in cellular response to glucose stimulus
vasoconstriction
positive regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of vasoconstriction
cardiac conduction
calcium ion transmembrane transport
positive regulation of canonical Wnt signaling pathway
positive regulation of atrial cardiac muscle cell action potential
positive regulation of adipose tissue development
positive regulation of regulation of vascular smooth muscle cell membrane depolarization
immune system process
transport
ion transport
cation transport
calcium ion transport
ion transmembrane transport
regulation of ion transmembrane transport
regulation of membrane potential
transmembrane transport
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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