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Proteintech
TSLP Polyclonal Antibody
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Product Details
13778-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TSLP Fusion Protein Ag4771 (1-60 aa encoded by BC016720)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKTKAALAI WCPGYSETQI NATQAMKKRR KRKVTTNKCL EQVSQLQGLW RRFNRPLLKQ Q (1-60 aa encoded by BC016720)
Target Information
TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytokine; short-chain four-helical bundle cytokine; Thymic stromal lymphopoietin
Gene Aliases: TSLP
UniProt ID: (Human) Q969D9
Entrez Gene ID: (Human) 85480
positive regulation of cytokine-mediated signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
positive regulation of chemokine production
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
positive regulation of interleukin-5 production
positive regulation of interleukin-6 production
positive regulation of mast cell activation
interleukin-7-mediated signaling pathway
negative regulation of apoptotic process
positive regulation of inflammatory response
defense response to Gram-negative bacterium
defense response to fungus
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of chemokine (C-C motif) ligand 1 production
positive regulation of granulocyte colony-stimulating factor production
positive regulation of STAT cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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