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Invitrogen
TWEAK Polyclonal Antibody
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FIGURE: 1 / 7
TWEAK Antibody (PA5-20211) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human brain tissue using TWEAK Polyclonal Antibody (Product # PA5-20211) at 10 µg/mL. Tissue was fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4˚C. A goat anti-rabbit IgG H&L (HRP) at 1/250 was used as secondary. ... View More
Product Details
PA5-20211
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
recombinant human TWEAK.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human brain tissue lysate.
Target Information
TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APO3 ligand; APO3/DR3 ligand; MGC129581; MGC20669; TNF-related WEAK inducer of apoptosis; tumor necrosis factor (ligand) superfamily member 12; tumor necrosis factor (ligand) superfamily, member 12; tumor necrosis factor ligand 4A; Tumor necrosis factor ligand superfamily member 12; TWEAK
Gene Aliases: APO3L; Dr3l; DR3LG; TNFSF12; TNLG4A; TWEAK; UNQ181/PRO207
UniProt ID: (Human) O43508, (Mouse) O54907
Entrez Gene ID: (Human) 8742, (Mouse) 21944
angiogenesis
positive regulation of endothelial cell proliferation
apoptotic process
immune response
signal transduction
cell differentiation
tumor necrosis factor-mediated signaling pathway
endothelial cell migration
positive regulation of protein catabolic process
positive regulation of angiogenesis
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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