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Staining of non-transfected (top) and human CD266-transfected (bottom) L5178Y cells with 0.25 ug of Mouse IgG1 kappa Isotype Control PE (open histogram) or 0.25 ug of Anti-Human CD266 (TWEAK Receptor) PE (filled histogram, A18427). Total viable cells were used for analysis.
|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1, kappa|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by biding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in aorta and liver. It may also play a role in vascular cell migration and angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
TWEAKR, FN14, CD266
FGF-inducible 14, fibroblast growth factor-inducible immediate-early response protein 14, tumor necrosis factor receptor superfamily member 12A, tweak-receptor, type I transmembrane protein Fn14, CD266, FN14, TWEAKR