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Bioss
Tal1 Polyclonal Antibody
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Product Details
BS-9428R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Tal1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TAL-1 is a basic helix-loop-helix transcription. It regulates differentiation and survival during hemopoiesis. TAL-1 is also implicated in the genesis of hemopoietic malignancies and it may play an important role in hemopoietic differentiation. It serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 is know to bind to the LIM domain containing protein Rhombotin-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TAL-1; tal-1 product
Gene Aliases: BHLHA17; SCL; SCL/tal-1; Tal-1; TAL1; TCL5
UniProt ID: (Human) P17542, (Mouse) P22091
Entrez Gene ID: (Human) 6886, (Rat) 313507, (Mouse) 21349
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
histone deacetylase binding
transcription regulatory region DNA binding
protein heterodimerization activity
E-box binding
transcription regulatory region sequence-specific DNA binding
molecular_function
DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
locomotory behavior
spinal cord association neuron differentiation
hemopoiesis
erythrocyte differentiation
megakaryocyte differentiation
platelet formation
basophil differentiation
positive regulation of protein complex assembly
embryonic hemopoiesis
megakaryocyte development
regulation of cell proliferation
erythrocyte maturation
cell fate commitment
positive regulation of erythrocyte differentiation
positive regulation of chromatin assembly or disassembly
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell division
astrocyte fate commitment
definitive hemopoiesis
hemangioblast cell differentiation
hematopoietic stem cell differentiation
regulation of mast cell differentiation
regulation of stem cell population maintenance
transcription from RNA polymerase II promoter
biological_process
myeloid cell differentiation
neuron differentiation
regulation of myeloid cell differentiation
generation of neurons
regulation of transcription, DNA-templated
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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