|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:500-1:2000|
|Western Blot (WB)||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||See 3 publications below|
|Immunocytochemistry (ICC)||See 4 publications below|
|Western Blot (WB)||See 55 publications below|
|Blocking Assay (BLOCK)||See 1 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Immunohistochemistry (IHC)||See 23 publications below|
|Immunohistochemistry - Free Floating (IHC (Free))||See 1 publications below|
|Immunoprecipitation (IP)||See 2 publications below|
|ELISA (ELISA)||See 6 publications below|
|Tested Species reactivity||Bovine, Human|
|Published species reactivity||Rat , Non-human primate , Human , Mouse|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK.|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MN1000 targets Tau in ELISA, IF, ICC, IHC (P), and WB applications and shows reactivity with Bovine, and Human samples.
The MN1000 immunogen is purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), corresponding to the amino acid sequence PPGQK.
MN1000 detects Tau which has a predicted molecular weight of approximately 79 kDa.
Paired helical filament (PHF) is a major component of the neurofibrillary tangles involved in the pathology of Alzheimer and quote;s disease. PHFs are composed of the microtubule-associated protein tau in a hyper-phosphorylated state (ref1). Tau protein is produced by a single gene expressed predominantly in neurons. The Tau gene undergoes complex alternative splicing, yielding six different isoforms of tau in the adult brain. Following translation, the tau protein can be further modified by phosphorylation at several different sites
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein beta1/gamma2 subunit-interacting factor 1; microtubule associated protein tau; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; protein phosphatase 1, regulatory subunit 103
Gene Aliases: BOS_19251; DDPAC; FTDP-17; MAPT; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
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