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Proteintech
Titin Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-27867
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Titin fusion protein Ag27496
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MFKSIHEKV SKISETKKSD QKTTESTVTR KTEPKAPEPI SSKPVIVTGL QDTTVSSDSV AKFAVKATGE PRPTAIWTKD GKAITQGGKY KLSEDKGGFF LEIHKTDTSD SGLYTCTVKN SAGSVSSSCK LTIKAIKDTE AQKVSTQKTS EITPQKKAVV QEEISQKALR SEEIKMSEAK SQEKLALKEE ASKVLISEEV KKSAATSLEK SIVHEEITKT SQASEEVRTH AEIK
Target Information
Monoclonal Anti-Titin can be used for study of the elastic filaments within sarcomeric structures. It is also useful as a differentiation marker in the separation of rhabdomyosarcomas from other muscle tumors. By indirect immunofluorescence the antibody displays a typical striated staining pattern on frozen sections of chicken skeletal and cardiac muscle tissues. Stains the region of the A-I junction by indirect immunofluorescence. It shows a decoration line 0.05 mm from the end of the A band in electron micro-graphs. In immunoblotting using total extracts of chicken breast muscle the antibody reacts specifically with both bands of the titin doublet, and showed no reaction with nebulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2.7.11.1; Connectin; DKFZp451N061; FLJ26020; FLJ26409; FLJ32040; FLJ34413; FLJ39564; FLJ43066; Rhabdomyosarcoma antigen MU-RMS-40.14; Titin; ttn
Gene Aliases: 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; AF006999; AV006427; CMD1G; CMH9; CMPD4; D330041I19Rik; D830007G01Rik; EOMFC; HMERF; L56; LGMD2J; mdm; MYLK5; shru; TMD; TTN
UniProt ID: (Human) Q8WZ42
Entrez Gene ID: (Human) 7273, (Mouse) 22138
protease binding
protein serine/threonine kinase activity
protein tyrosine kinase activity
calcium ion binding
protein binding
calmodulin binding
ATP binding
structural constituent of muscle
enzyme binding
protein kinase binding
telethonin binding
identical protein binding
actinin binding
protein self-association
actin filament binding
muscle alpha-actinin binding
structural molecule activity conferring elasticity
structural constituent of cytoskeleton
immunoglobulin receptor superfamily
platelet degranulation
cardiac muscle hypertrophy
muscle contraction
striated muscle contraction
mitotic chromosome condensation
peptidyl-tyrosine phosphorylation
muscle filament sliding
skeletal muscle thin filament assembly
skeletal muscle myosin thick filament assembly
detection of muscle stretch
sarcomere organization
regulation of protein kinase activity
cardiac muscle fiber development
sarcomerogenesis
regulation of catalytic activity
response to calcium ion
cardiac myofibril assembly
cardiac muscle tissue morphogenesis
cardiac muscle contraction
in utero embryonic development
heart morphogenesis
adult heart development
ventricular system development
forward locomotion
striated muscle cell development
heart growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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