Proteintech

Transferrin Polyclonal Antibody

Transferrin Antibody in Immunocytochemistry (ICC/IF)

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Transferrin Antibody (17435-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using (Product # 17435-1-AP) (Transferrin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Transferrin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Transferrin Antibody in Western Blot (WB)

Product Image Gallery

Product Details

17435-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 32 publications 32 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Transferrin Fusion Protein Ag11504 (347-698 aa encoded by BC059367)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EGTCQEAPT DECKPVKWCA LSHHERLKCD EWSVNSVGKI ECVSAETTED CIAKIMNGEA DAMSLDGGFV YIAGKCGLVP VLAENYNKSD NCEDTPEAGY FAVAVVKKSA SDLTWDNLKG KKSCHTAVGR TAGWNIPMGL LYNKINHCRF DEFFSEGCAP GSKKDSSLCK LCMGSGLNLC EPNNKEGYYG YTGAFRCLVE KGDVAFVKHQ TVPQNTGGKN PDPWAKNLNE KDYELLCLDG TRKPVEEYAN CHLARAPNHA VVTRKDKEAC VHKILRQQQH LFGSNVTDCS GNFCLFRSET KDLLFRDDTV CLAKLHDRNT YEKYLGEEYV KAVGNLRKCS TSSLLEACTF RRP (347-698 aa encoded by BC059367)

Target Information

Transferrins (Tf) are an approximately 80kDa blood plasma glycoprotein synthesized by the liver. They are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Transferrin is the primary blood iron transport protein and under normal conditions; approximately one-third of total blood transferrin contains bound iron. Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis.Serum transferrin may also have a further role in stimulating cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Sun Jan 01 00:00:00 UTC 2023

Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin.

Proceedings of the National Academy of Sciences of the United States of America

Thepsuwan P,Bhattacharya A,Song Z,Hippleheuser S,Feng S,Wei X,Das NK,Sierra M,Wei J,Fang D,Huang YM,Zhang K,Shah YM,Sun S

Tue Jan 10 00:00:00 UTC 2023

Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.

International immunopharmacology

Dong C,Song C,He Z,Song Q,Song T,Liu J,Xiong Y,Su X,Zhou J,Yang S,Liao W

Sat Apr 01 00:00:00 UTC 2023

Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.

Molecular neurobiology

Liu C,Tian Q,Wang J,He P,Han S,Guo Y,Yang C,Wang G,Wei H,Li M

Wed Feb 01 00:00:00 UTC 2023

Myelin regulatory factor is a target of individual and interactive effects of HIV-1 Tat and morphine in the striatum and pre-frontal cortex.

Journal of neurovirology

Flounlacker KM,Hahn YK,Xu R,Simons CA,Tian T,Hauser KF,Knapp PE

Wed Feb 01 00:00:00 UTC 2023

Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier.

bioRxiv : the preprint server for biology

Baringer SL,Palsa K,Simpson IA,Connor JR

Tue Jan 10 00:00:00 UTC 2023

Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient Mice.

International journal of molecular sciences

Kessel JC,Weiskirchen R,Schröder SK

Thu May 25 00:00:00 UTC 2023

Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma.

International journal of oncology

Chen Q,Zhang L,Wan C,Yang B,Kong X,Xu X,Gu Y,Wang C,Liu X,Ding Q,Zhu L,Li Y,Wang B,Zhong W

Sat Jul 01 00:00:00 UTC 2023

Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction.

Free radical biology & medicine

Xie J,Lv H,Liu X,Xia Z,Li J,Hong E,Ding B,Zhang W,Chen Y

Sat Apr 01 00:00:00 UTC 2023

Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction.

Free radical biology & medicine

Xie J,Lv H,Liu X,Xia Z,Li J,Hong E,Ding B,Zhang W,Chen Y

Sat Apr 01 00:00:00 UTC 2023

Opening K_ATP channels induces inflammatory tolerance and prevents chronic pain.

Brain, behavior, and immunity

Qian C,Fan Y,Zong L,Miao C,Ji LL,Wan L,Jia R,Qin X,Wang Y,Wu Q,Tao XY,Hao L,Hu L,Liu WT

Sun Jan 01 00:00:00 UTC 2023

Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier.

Research square

Baringer S,Palsa K,Simpson IA,Connor JR

Tue Jan 17 00:00:00 UTC 2023

Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.

The FEBS journal

Kuang H,Sun X,Liu Y,Tang M,Wei Y,Shi Y,Li R,Xiao G,Kang J,Wang F,Peng J,Xu H,Zhou F

Sat Jul 01 00:00:00 UTC 2023

Single cell RNA-seq analysis identifies ferroptotic chondrocyte cluster and reveals TRPV1 as an anti-ferroptotic target in osteoarthritis.

EBioMedicine

Lv Z,Han J,Li J,Guo H,Fei Y,Sun Z,Dong J,Wang M,Fan C,Li W,Xie Y,Sun W,Chen J,Liu Y,Chen F,Liu Z,Liu A,Wu R,Xu X,Yan W,Jiang Q,Ikegawa S,Chen X,Shi D

Sat Oct 01 00:00:00 UTC 2022

The adipocyte-enriched secretory protein tetranectin exacerbates type 2 diabetes by inhibiting insulin secretion from β cells.

Science advances

Liu F,Cai Z,Yang Y,Plasko G,Zhao P,Wu X,Tang C,Li D,Li T,Hu S,Song L,Yu S,Xu R,Luo H,Fan L,Wang E,Xiao Z,Ji Y,Zeng R,Li R,Bai J,Zhou Z,Liu F,Zhang J

Fri Sep 23 00:00:00 UTC 2022

Patulin Induces Acute Kidney Injury in Mice through Autophagy-Ferroptosis Pathway.

Journal of agricultural and food chemistry

Hou Y,Wang S,Jiang L,Sun X,Li J,Wang N,Liu X,Yao X,Zhang C,Deng H,Yang G

Wed May 25 00:00:00 UTC 2022

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.

Clinical and translational medicine

Li B,Wang Z,Hong J,Che Y,Chen R,Hu Z,Hu X,Wu Q,Hu J,Zhang M

Fri Jan 01 00:00:00 UTC 2021

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.

Clinical and translational medicine

Li B,Wang Z,Hong J,Che Y,Chen R,Hu Z,Hu X,Wu Q,Hu J,Zhang M

Fri Jan 01 00:00:00 UTC 2021

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.

Clinical and translational medicine

Li B,Wang Z,Hong J,Che Y,Chen R,Hu Z,Hu X,Wu Q,Hu J,Zhang M

Fri Jan 01 00:00:00 UTC 2021

Iron deficiency promotes aortic medial degeneration via destructing cytoskeleton of vascular smooth muscle cells.

Clinical and translational medicine

Li B,Wang Z,Hong J,Che Y,Chen R,Hu Z,Hu X,Wu Q,Hu J,Zhang M

Fri Jan 01 00:00:00 UTC 2021

Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements.

Scientific reports

Zhang Q,Lu XM,Zhang M,Yang CY,Lv SY,Li SF,Zhong CY,Geng SS

Thu Jan 14 00:00:00 UTC 2021

Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.

International journal of molecular medicine

He Z,Liao W,Song Q,Li B,Liu J,Xiong Y,Song C,Yang S

Fri Jan 01 00:00:00 UTC 2021

Precise Investigation of the Efficacy of Multicomponent Drugs Against Pneumonia Infected With Influenza Virus.

Frontiers in pharmacology

Wei J,Sun J,Zeng J,Ji E,Xu J,Tang C,Huo H,Zhang Y,Li H,Yang H

Tue Dec 07 00:00:00 UTC 2021

Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.

Archives of pharmacal research

Zheng X,Liu H,Ma M,Ji J,Zhu F,Sun L

Thu Apr 01 00:00:00 UTC 2021

Features of Lipid Metabolism in Humanized ApoE Knockin Rat Models.

International journal of molecular sciences

Wu Y,Johnson G,Zhao F,Wu Y,Zhao G,Brown A,You S,Zou MH,Song P

Sat Jul 31 00:00:00 UTC 2021

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood-brain barrier and attenuates their targeting ability to brain tumor.

Biomaterials

Xiao W,Wang Y,Zhang H,Liu Y,Xie R,He X,Zhou Y,Liang L,Gao H

Thu Jul 01 00:00:00 UTC 2021

Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages.

Journal of translational medicine

Sun JL,Zhang NP,Xu RC,Zhang GC,Liu ZY,Abuduwaili W,Wang F,Yu XN,Shi X,Song GQ,Wu H,Liu TT,Shen XZ,Deng B,Weng SQ,Dong L,Zhu JM

Fri Aug 13 00:00:00 UTC 2021

Upregulation of C Terminus of Hsc70-Interacting Protein Attenuates Apoptosis and Procoagulant Activity and Facilitates Brain Repair After Traumatic Brain Injury.

Frontiers in neuroscience

Chen H,Jing Y,Xu Z,Yang D,Ju S,Guo Y,Tian H,Xue L

Wed Nov 29 00:00:00 UTC 2023

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Molecular cell

Weber RA,Yen FS,Nicholson SPV,Alwaseem H,Bayraktar EC,Alam M,Timson RC,La K,Abu-Remaileh M,Molina H,Birsoy K

Thu Feb 06 00:00:00 UTC 2020

Comprehensive lipidomics in apoM^-/- mice reveals an overall state of metabolic distress and attenuated hepatic lipid secretion into the circulation.

Journal of genetics and genomics = Yi chuan xue bao

Shi Y,Lam SM,Liu H,Luo G,Zhang J,Yao S,Li J,Zheng L,Xu N,Zhang X,Shui G

Sun Sep 20 00:00:00 UTC 2020

Bisphenol A Deranges the Endocannabinoid System of Primary Sertoli Cells with an Impact on Inhibin B Production.

International journal of molecular sciences

Rossi G,Dufrusine B,Lizzi AR,Luzi C,Piccoli A,Fezza F,Iorio R,D'Andrea G,Dainese E,Cecconi S,Maccarrone M

Thu Nov 26 00:00:00 UTC 2020

Increased expression levels of inflammatory cytokines and adhesion molecules in lipopolysaccharide‑induced acute inflammatory apoM‑/‑ mice.

Molecular medicine reports

Shi Y,Liu H,Liu H,Yu Y,Zhang J,Li Y,Luo G,Zhang X,Xu N

Thu Oct 01 00:00:00 UTC 2020

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess.

Haematologica

Mercadante CJ,Prajapati M,Parmar JH,Conboy HL,Dash ME,Pettiglio MA,Herrera C,Bu JT,Stopa EG,Mendes P,Bartnikas TB

Mon Apr 01 00:00:00 UTC 2019

Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess.

Haematologica

Mercadante CJ,Prajapati M,Parmar JH,Conboy HL,Dash ME,Pettiglio MA,Herrera C,Bu JT,Stopa EG,Mendes P,Bartnikas TB

Mon Apr 01 00:00:00 UTC 2019

The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.

Ecotoxicology and environmental safety

Wang Q,Wang HX,Shen JY,Zhang R,Hong JW,Li Z,Chen G,Li MX,Ding Z,Li J,Zhang JP,Zhang MR,Xu LC

Thu Aug 15 00:00:00 UTC 2019

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.

Cell & bioscience

Niu L,Ye C,Sun Y,Peng T,Yang S,Wang W,Li H

Fri Mar 18 00:00:00 UTC 2022

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.

Cell & bioscience

Niu L,Ye C,Sun Y,Peng T,Yang S,Wang W,Li H

Fri Mar 18 00:00:00 UTC 2022

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.

Cell & bioscience

Niu L,Ye C,Sun Y,Peng T,Yang S,Wang W,Li H

Fri Mar 18 00:00:00 UTC 2022

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease.

Cell & bioscience

Niu L,Ye C,Sun Y,Peng T,Yang S,Wang W,Li H

Fri Mar 18 00:00:00 UTC 2022

Dysregulated expression of antioxidant enzymes in polyethylene particle-induced periprosthetic inflammation and osteolysis.

PloS one

Peng KT,Tsai MH,Lee CW,Chiang YC,Chen PC,Chen CC,Chang CH,Shih HN,Chang PJ

Mon Feb 04 00:00:00 UTC 2019

NF-κB p65 Knock-down inhibits TF, PAI-1 and promotes activated protein C production in lipopolysaccharide-stimulated alveolar epithelial cells type II.

Experimental lung research

Liu B,Wu Y,Wang Y,Cheng Y,Yao L,Liu Y,Qian H,Yang H,Shen F

Fri Feb 15 00:00:00 UTC 2019

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

International journal of molecular sciences

Liu Y,Su X,Hao J,Chen M,Liu W,Liao X,Li G

Wed Jan 13 00:00:00 UTC 2016

Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice.

International journal of molecular sciences

Liu Y,Su X,Hao J,Chen M,Liu W,Liao X,Li G

Wed Jan 13 00:00:00 UTC 2016

Lipid A-activated inducible nitric oxide synthase expression via nuclear factor-κB in mouse choroid plexus cells.

Immunology letters

Takano M,Ohkusa M,Otani M,Min KS,Kadoyama K,Minami K,Sano K,Matsuyama S

Thu Oct 01 00:00:00 UTC 2015

Lipid A-activated inducible nitric oxide synthase expression via nuclear factor-κB in mouse choroid plexus cells.

Immunology letters

Takano M,Ohkusa M,Otani M,Min KS,Kadoyama K,Minami K,Sano K,Matsuyama S

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CXCR7 correlates with the differentiation of hepatocellular carcinoma and suppresses HNF4α expression through the ERK pathway.

Oncology reports

Xue TC,Jia QA,Bu Y,Chen RX,Cui JF,Tang ZY,Ye SL

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Investigating the role of transferrin in the distribution of iron, manganese, copper, and zinc.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

Herrera C,Pettiglio MA,Bartnikas TB

Fri Aug 01 00:00:00 UTC 2014

Investigating the role of transferrin in the distribution of iron, manganese, copper, and zinc.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

Herrera C,Pettiglio MA,Bartnikas TB

Fri Aug 01 00:00:00 UTC 2014

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

The Journal of biological chemistry

Patil H,Saha A,Senda E,Cho KI,Haque M,Yu M,Qiu S,Yoon D,Hao Y,Peachey NS,Ferreira PA

Fri Oct 24 00:00:00 UTC 2014

The Journal of biological chemistry

Patil H,Saha A,Senda E,Cho KI,Haque M,Yu M,Qiu S,Yoon D,Hao Y,Peachey NS,Ferreira PA

Fri Oct 24 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Beta-1 metal-binding globulin; DKFZp781D0156; epididymis secretory sperm binding protein Li 71p; hypotransferrinemia with hemochromatosis; Liver regeneration-related protein LRRG03; Serotransferrin; Siderophilin; transferin; Transferrin

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Gene Aliases: AI266983; Cd176; HEL-S-71p; HP; hpx; PRO1400; PRO1557; PRO2086; TF; Tfn; TFQTL1; Trf

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UniProt ID: (Human) P02787, (Rat) Q64630, (Mouse) Q921I1

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Entrez Gene ID: (Human) 7018, (Rat) 24825, (Mouse) 22041

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Function(s)

protein binding ferrous iron binding ferric iron binding ferric iron transmembrane transporter activity transferrin receptor binding GTP binding metal ion binding transfer/carrier protein

Process(es)

retina homeostasis platelet degranulation cellular iron ion homeostasis regulation of protein stability transferrin transport positive regulation of receptor-mediated endocytosis iron ion homeostasis cellular response to iron ion ferrous iron import into cell response to hypoxia iron ion transport apoptotic process acute-phase response actin filament organization activation of JUN kinase activity small GTPase mediated signal transduction response to lead ion response to organic cyclic compound ferric iron transport osteoclast differentiation positive regulation of myelination positive regulation of phosphorylation positive regulation of bone resorption positive regulation of transcription, DNA-templated SMAD protein signal transduction ERK1 and ERK2 cascade positive regulation of oligodendrocyte progenitor proliferation cellular response to cAMP cellular response to follicle-stimulating hormone stimulus positive regulation of cell motility transport ion transport iron ion transmembrane transport

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Transferrin Polyclonal Antibody

Transferrin Antibody (17435-1-AP) in ICC/IF

Product Details

17435-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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