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Proteintech
Transferrin Receptor 2/TFR2 Polyclonal Antibody
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FIGURE: 1 / 2
Transferrin Receptor 2/TFR2 Antibody (32381-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 32381-1-AP (Transferrin Receptor 2/TFR2 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Product Details
32381-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Transferrin Receptor 2/TFR2 fusion protein Ag37959
Conjugate
Form
Liquid
Concentration
400 µg/mL
Amount
60 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: RGSCQACGDS VLVVSEDVNY EPDLDFHQGR LYWSDLQAMF LQFLGEGRLE DTIRQTSLRE RVAGSAGMAA LTQDIRAALS RQKLDHVWTD THYVGLQFPD PAHPNTLHWV DEAGKVGEQL PLEDPDVYCP YSAIGNVTGE LVYAHYGRPE DLQDLRARGV DPVGRLLLVR VGVISFAQKV TNAQDFGAQG VLIYPEPADF SQDPPK
Target Information
This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126368; TfR2; Transferrin receptor protein 2; unnamed protein product
Gene Aliases: HFE3; TFR2; TFRC2; Trfr2
UniProt ID: (Human) Q9UP52, (Rat) B2GUY2, (Mouse) Q9JKX3
Entrez Gene ID: (Human) 7036, (Rat) 288562, (Mouse) 50765
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
response to iron ion
transferrin transport
positive regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
multicellular organismal iron ion homeostasis
cellular response to iron ion
positive regulation of peptide hormone secretion
endocytic iron import into cell
positive regulation of protein maturation
biological_process
iron ion homeostasis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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