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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 297 of Human UBE1L|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-27997 targets UBE1L in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-27997 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 297 of Human UBE1L.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
D8; UBA1; UBA1, ubiquitin-activating enzyme E1 homolog B; UBA1B; UBA7; UBA7, ubiquitin-activating enzyme E1; UBE1L; UBE2; Ubiquitin-activating enzyme 7; ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1 homolog B; ubiquitin-activating enzyme E1-related protein; ubiquitin-activating enzyme-2; ubiquitin-like modifier activating enzyme 7; ubiquitin-like modifier-a; Ubiquitin-like modifier-activating enzyme 7
D8; UBA1B; UBA7; UBE1L; UBE2