The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme C; cyclin-selective ubiquitin carrier protein; dJ447F3.2; E2 ubiquitin-conjugating enzyme C; mitotic-specific ubiquitin-conjugating enzyme; RP3-447F3.1; UBCH10; UBE2C; Ubiquitin carrier protein C; ubiquitin carrier protein E2-C; ubiquitin conjugating enzyme E2C; Ubiquitin-conjugating enzyme E2 C; ubiquitin-conjugating enzyme E2C; Ubiquitin-protein ligase C
Gene Aliases: dJ447F3.2; UBCH10; UBE2C
UniProt ID: (Human) O00762
Entrez Gene ID: (Human) 11065