FIGURE: 1 / 3
Immunogen sequence: NLSSDDANVL VWHALLLPDQ PPYHLKAFNL RISFPPEYPF KPPMIKFTTK IYHPNVDENG QICLPIISSE NWKPCTKTCQ VLEALNVLVN RPNIREPLRM DLADLLTQNP ELFRKNAEEF TLR
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 74%.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.
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Protein Aliases: E2 ubiquitin-conjugating enzyme L6; MGC40331; retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; ubiquitin conjugating enzyme E2L 6; ubiquitin-conjugating enzyme E2L 6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15-conjugating enzyme E2 L6
Gene Aliases: RIG-B; UBCH8; UBE2L6
UniProt ID: (Human) O14933
Entrez Gene ID: (Human) 9246
Molecular Function: ubiquitin-protein ligase