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Product Details
H00063893-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UBE2O (AAH51868.2, 1 a.a. approximately 741 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTSADVMWQD GSVECNIRSN DLFPVHHLDN NEFCPGDFVV DKRVQSCPDP AVYGVVQSGD HIGRTCMVKW FKLRPSGDDV ELIGEEEDVS VYDIADHPDF RFRTTDIVIR IGNTEDGAPH KEDEPSVGQV ARVDVSSKVE VVWADNSKTI ILPQHLYNIE SEIEESDYDS VEGSTSGASS DEWEDDSDSW ETDNGLVEDE HPKIEEPPIP PLEQPVAPED KGVVISEEAA TAAVQGAVAM AAPMAGLMEK AGKDGPPKSF RELKEAIKIL ESLKNMTVEQ LLTGSPTSPT VEPEKPTREK KFLDDIKKLQ ENLKKTLDNV AIVEEEKMEA VPDVERKEDK PEGQSPVKAE WPSETPVLCQ QCGGKPGVTF TSAKGEVFSV LEFAPSNHSF KKIEFQPPEA KKFFSTVRKE MALLATSLPE GIMVKTFEDR MDLFSALIKG PTRTPYEDGL YLFDIQLPNI YPAVPPHFCY LSQCSGRLNP NLYDNGKVCV SLLGTWIGKG TERWTSKSSL LQVLISIQGL ILVNEPYYNE AGFDSDRGLQ EGYENSRCYN EMALIRVVQS MTQLVRRPPE VFEQEIRQHF STGGWRLVNR IESWLETHAL LEKAQALPNG VPKASSSPEP PAVAELSDSG QQEPEDGGPA PGEASQGSDS EGGAQGLASA SRDHTDQTSE TAPDASVPPS VKPKKRRKSY RSFLPEKSGY PDIGFPLFPL SKGFIKSIRG VLTQFRAALL EAGMPECTED K
Target Information
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase UBE2O; Ubiquitin carrier protein O; ubiquitin conjugating enzyme E2O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; ubiquitin-conjugating enzyme E2O; Ubiquitin-protein ligase O
Gene Aliases: E2-230K; KIAA1734; UBE2O
UniProt ID: (Human) Q69YP4
Entrez Gene ID: (Human) 63893
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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