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Product Details
PA5-22329
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:10,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fragment corresponding to a region within amino acids 291 and 530 of UGT1A9 (Uniprot ID#O60656) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.47 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
0.1M tris glycine, pH 7, with 20% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_11157002 |
Product Specific Information
Recommended positive controls: H1299, HeLa, HepG2, mouse liver.
Predicted reactivity: Mouse (90%), Rat (89%), Sheep (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
UGT1A9 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A9 is active on phenols.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lugP4; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family polypeptide A12; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1 family polypeptide A9s; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UDPGT 1-9; UGT-1I; UGT1A12; UGT1A9; UGTP4
Gene Aliases: GNT1; HLUGP4; LUGP4; mUGTBr/P; UDPGT; UDPGT 1-9; UGT-1I; UGT1; UGT1-09; UGT1-9; UGT1.9; Ugt1a12; UGT1A9; UGT1A9S; UGT1AI; UGT1I; UGTP4
UniProt ID: (Human) O60656, (Mouse) Q62452
Entrez Gene ID: (Human) 54600, (Mouse) 394434
Molecular Function:
glycosyltransferase
retinoic acid binding
glucuronosyltransferase activity
protein homodimerization activity
protein heterodimerization activity
enzyme inhibitor activity
protein kinase C binding
steroid binding
fatty acid binding
drug binding
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
enzyme binding
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