Predicted to react with Mouse and Rat samples.
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KIAA1976netrin receptor UNC5A; Netrin receptor UNC5A; netrin receptor Unc5h1; Protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc-5 homolog 1; unc-5 homolog A; unc-5 homolog A (C. elegans); unc5 (C.elegans homolog) a; unc5 homolog 1; UNC5A; UNC5H1FLJ16449
Gene Aliases: KIAA1976; mKIAA1976; UNC5A; UNC5H1
Molecular Function: receptor