Search Thermo Fisher Scientific
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Immunogen sequence: KTGLSTLLGI LYEDKERQDF IFTIYHWWQA VAIFTVYLGS SLHMKAKLAV LLVTLVAAAV SYLRMEQKLR RGVAPRQPRI PRPQHKVRGY RYLEEDNSDE S; Positive Samples: 293T, HeLa, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney, Rat lung, Rat spleen; Cellular Location: Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Lysosome, Multi-pass membrane protein, phagosome
The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hUNC93B1; Protein unc-93 homolog B1; unc-93 homolog B; unc-93 related protein; Unc-93B1; unc93 homolog B; unc93 homolog B1
Gene Aliases: IIAE1; Unc-93B1; UNC93; UNC93B; UNC93B1
UniProt ID: (Human) Q9H1C4, (Mouse) Q8VCW4
Entrez Gene ID: (Human) 81622, (Rat) 361689, (Mouse) 54445
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