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Immunogen sequence: MAAPLSVEVE FGGGAELLFD GIKKHRVTLP GQEEPWDIRN LLIWIKKNLL KERPELFIQG DSV; Positive Samples: Rat eye; Cellular Location: Cytoplasm
Following the discovery of protein modification by the small, highly conserved ubiquitin polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function as protein modifiers as well. These Ubls, which include SUMO, ISG15, Nedd8, and Atg8, function as critical regulators of many cellular processes, including transcription, DNA repair, signal transduction, autophagy, and cell-cycle control. A growing body of data also implicates the dysregulation of Ubl-substrate modification and mutations in the Ubl-conjugation machinery in the etiology and progression of a number of human diseases. URM1 is a ubiquitin-like modifier protein.
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Protein Aliases: MGC2668; RP11-339B21.4; Ubiquitin-related modifier 1; ubiquitin-related modifier 1 homolog
Gene Aliases: 2900073H19Rik; RGD1306599; Urm1
UniProt ID: (Mouse) Q9D2P4
Entrez Gene ID: (Mouse) 68205, (Rat) 311840
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