FIGURE: 1 / 2
Immunogen sequence: ALVPYLVGQV VAGAQALQLF ESHAGHLGPQ LFNKFALPYI RDVAKQVKAR LREAGLAPVP MIIFAKDGHF
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.
This gene encodes the fifth enzyme of the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.
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Protein Aliases: UPD; URO D; Uroporphyrinogen decarboxylase; uroporphyrinogen III decarboxylase
Gene Aliases: PCT; UPD; UROD
UniProt ID: (Human) P06132
Entrez Gene ID: (Human) 7389
Molecular Function: methyltransferase