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Proteintech
USP49 Polyclonal Antibody
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Product Details
18066-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
USP49 Fusion Protein Ag12697 (1-352 aa encoded by BC014176)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDRCKHVGR LRLAQDHSIL NPQKWCCLEC ATTESVWACL KCSHVACGRY IEDHALKHFE ETGHPLAMEV RDLYVFCYLC KDYVLNDNPE GDLKLLRSSL LAVRGQKQDT PVRRGRTLRS MASGEDVVLP QRAPQGQPQM LTALWYRRQR LLARTLRLWF EKSSRGQAKL EQRRQEEALE RKKEEARRRR REVKRRLLEE LASTPPRKSA RLLLHTPRDA GPAASRPAAL PTSRRVPAAT LKLRRQPAMA PGVTGLRNLG NTCYMNSILQ VLSHLQKFRE CFLNLDPSKT EHLFPKATNG KTQLSGKPTN SSATELSLRN DRAEACEREG FCWNGRASIS RSLELIQNKE PSS (1-352 aa encoded by BC014176)
Target Information
Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Deubiquitinating enzyme 49; Ubiquitin carboxyl-terminal hydrolase 49; ubiquitin specific protease 49; Ubiquitin thioesterase 49; ubiquitin thiolesterase 49; Ubiquitin-specific-processing protease 49
Gene Aliases: C330046L10Rik; Gm545; RGD1310513; USP49
UniProt ID: (Human) Q70CQ1, (Mouse) Q6P9L4
Entrez Gene ID: (Human) 25862, (Mouse) 224836, (Rat) 316211
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
hydrolase activity
histone binding
metal ion binding
histone H2B deubiquitinase activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
mRNA splicing, via spliceosome
chromatin organization
chromatin remodeling
mRNA processing
proteolysis
RNA splicing
protein deubiquitination
protein kinase B signaling
negative regulation of protein kinase B signaling
ubiquitin-dependent protein catabolic process
chromatin modification
histone H2B conserved C-terminal lysine deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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