Immunogen sequence: MSAPAQPPAE GTEGTAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIIRV NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCK; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell junction, Cytoplasmic vesicle, Cytoplasmic vesicle membrane, Mitochondrion outer membrane, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome, synaptosome
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp686H12131; MRXSYP; synaptobrevin 1; Synaptobrevin-1; vamp; VAMP-1; Vesicle-associated membrane protein 1; vesicle-associated membrane protein 1 (synaptobrevin 1)
Gene Aliases: lew; SPAX1; Syb-1; SYB1; VAMP-1; VAMP1