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Invitrogen
VDAC Polyclonal Antibody
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FIGURE: 1 / 3
VDAC Antibody (PA5-141011) in ICC/IF
Immunocytochemistry analysis of VDAC1 in HeLa cells (green). Samples were incubated in VDAC1 Polyclonal antibody (Product # PA5-141011). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS and counterstained with DAPI in order to highlight the nucleus (blue).
Product Details
PA5-141011
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within human VDAC1 aa 188-231.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVDAC1; MGC111064; Mitochondrial Porin; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; VD; VDAC-1; Voltage-dependent anion-selective channel protein 1
Gene Aliases: fa13f11; PORIN; VDAC; VDAC-1; VDAC1; wu:fa13f11; zgc:85830
UniProt ID: (Human) P21796
Entrez Gene ID: (Human) 7416, (Zebrafish) 334582
behavioral fear response
anion transport
mitochondrial calcium ion transport
apoptotic process
neuron-neuron synaptic transmission
learning
viral process
macroautophagy
epithelial cell differentiation
anion transmembrane transport
regulation of mitophagy
regulation of anion transmembrane transport
negative regulation of reactive oxygen species metabolic process
transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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