|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified recombinant human VEGF.|
|Storage buffer||PBS, pH 7.5|
|Contains||0.05% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This product is recommended as a capture antibody in Sandwich ELISA applications.
The vascular endothelial growth factor (VEGF) family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
AHG0114 was used in immunohistochemistry to investigate the efficacy of deep-brain stimulation on microvascular integrity in the subthalamic nucleus in Parkinson disease
|Pienaar IS,Lee CH,Elson JL,McGuinness L,Gentleman SM,Kalaria RN,Dexter DT||Neurobiology of disease (74:392)||2015|
|Human||2.5 µg/ml||VEGF and VEGF receptor expression in human chronic critical limb ischaemia.||Choksy S,Pockley AG,Wajeh YE,Chan P||European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery (28:660)||2004|