This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: APARDELPDW NEVLPPWDRE EDEVYPPGPY HPFPNYIRPR TLQPPSALRR RHYHHALPPS RHYPGREAQA RRAQEEAEAE ERRLQEQEEL ENYIEHV
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Antimicrobial peptide VGF[554-577]; NERP-1; NERP-2; neuro-endocrine specific protein VGF; Neuroendocrine regulatory peptide-1; Neuroendocrine regulatory peptide-2; Neurosecretory protein VGF; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62
Gene Aliases: SCG7; SgVII; VGF
UniProt ID: (Human) Q9UDW8
Entrez Gene ID: (Human) 7425
Molecular Function: intercellular signal molecule