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Invitrogen
VMAT2 Polyclonal Antibody
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FIGURE: 1 / 1
VMAT2 Antibody (PA5-22864) in IHC
Immunohistochemistry analysis of VMAT2 was performed on human H1 huES teratoma tissue. To expose target proteins, antigen retrieval was performed using a pressure cooker in 10mM citric acid (pH 6.0). Following antigen retrieval, endogenous peroxidases were blocked with 2.5% hydrogen peroxide. Tissue slide was successively blocked with Avidin D, biotin and protein blocking buffer. Tissues were probed with a VMAT2 polyclonal antibody (Product # PA5-22864) diluted 1:100 overnight at 4°C. After washing tissue slide was incubated with biotinyla... View More
Product Details
PA5-22864
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Reacts with an internal sequence of the human, mouse and rat VMAT2 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
VMAT2 is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. It is a requisite for vesicular amine storage prior to secretion via exocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC120477; MGC120478; MGC26538; monoamine neurotransmitter transporter; Monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); Solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicle amine transporter, brain; synaptic vesicle monoamine transporter, brain; Synaptic vesicular amine transporter; unnamed protein product; VAT2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; Vesicular amine transporter 2; Vesicular monoamine transporter 2
Gene Aliases: 1110037L13Rik; 9330105E13; MNAT; PKDYS2; SLC18A2; SVAT; SVMT; VAT2; VMAT-2; VMAT2
UniProt ID: (Human) Q05940, (Mouse) Q8BRU6, (Rat) Q01827
Entrez Gene ID: (Rabbit) 100351780, (Human) 6571, (Mouse) 214084, (Rat) 25549
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
monoamine:proton antiporter activity
transmembrane transporter activity
amine transmembrane transporter activity
drug binding
serotonin transmembrane transporter activity
drug transmembrane transporter activity
enzyme binding
heat shock protein binding
secondary carrier transporter
response to amphetamine
serotonin secretion by mast cell
histamine secretion by mast cell
neurotransmitter transport
serotonin transport
chemical synaptic transmission
locomotory behavior
response to toxic substance
post-embryonic development
aminergic neurotransmitter loading into synaptic vesicle
monoamine transport
dopamine transport
serotonin uptake
histamine uptake
establishment of localization in cell
transmembrane transport
neurotransmitter loading into synaptic vesicle
somato-dendritic dopamine secretion
hydrogen ion transmembrane transport
negative regulation of reactive oxygen species biosynthetic process
transport
aging
organic cation transport
drug transport
obsolete death
insulin secretion
cellular response to drug
glucose homeostasis
negative regulation of neurotransmitter transport
ammonium transmembrane transport
drug transmembrane transport
response to herbicide
response to metal ion
response to zinc ion
endocytic recycling
response to cocaine
response to drug
response to starvation
response to corticosterone
cellular response to ammonium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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