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Invitrogen
VMAT2 Polyclonal Antibody
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Product Details
PA5-95650
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acid residues from the intracellular C-terminal region conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
VMAT2 is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. It is a requisite for vesicular amine storage prior to secretion via exocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC120477; MGC120478; MGC26538; monoamine neurotransmitter transporter; Monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); Solute carrier family 18 member 2; solute carrier family 18, member 2; synaptic vesicle amine transporter, brain; synaptic vesicle monoamine transporter, brain; Synaptic vesicular amine transporter; unnamed protein product; VAT2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; Vesicular amine transporter 2; Vesicular monoamine transporter 2
Gene Aliases: MNAT; PKDYS2; SLC18A2; SVAT; SVMT; VAT2; VMAT-2; VMAT2
UniProt ID: (Human) Q05940, (Rat) Q01827
Entrez Gene ID: (Human) 6571, (Rat) 25549
serotonin:sodium symporter activity
protein binding
monoamine transmembrane transporter activity
monoamine:proton antiporter activity
transmembrane transporter activity
amine transmembrane transporter activity
drug binding
serotonin transmembrane transporter activity
drug transmembrane transporter activity
enzyme binding
heat shock protein binding
secondary carrier transporter
response to amphetamine
serotonin secretion by mast cell
histamine secretion by mast cell
neurotransmitter transport
serotonin transport
chemical synaptic transmission
locomotory behavior
response to toxic substance
post-embryonic development
aminergic neurotransmitter loading into synaptic vesicle
monoamine transport
dopamine transport
serotonin uptake
histamine uptake
establishment of localization in cell
transmembrane transport
neurotransmitter loading into synaptic vesicle
somato-dendritic dopamine secretion
hydrogen ion transmembrane transport
negative regulation of reactive oxygen species biosynthetic process
drug transmembrane transport
aging
response to herbicide
response to metal ion
response to zinc ion
obsolete death
insulin secretion
endocytic recycling
cellular response to drug
response to cocaine
response to drug
glucose homeostasis
response to starvation
response to corticosterone
negative regulation of neurotransmitter transport
cellular response to ammonium ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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