This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.
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Protein Aliases: DKFZp547I194; RP5-1033B10; SAC2 suppressor of actin mutations 2-like protein; vacuolar protein sorting 52 homolog; Vacuolar protein sorting-associated protein 52 homolog; VPS52 GARP complex subunit
Gene Aliases: ARE1; D130068D18; D430041K17Rik; dJ1033B10.5; SAC2; SACM2L; tclw5; VPS52
Molecular Function: membrane traffic protein