PA5-28687 targets VRK1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28687 immunogen is recombinant fragment corresponding to a region within amino acids 153 and 396 of Human VRK1.
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This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
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Protein Aliases: PCH1; Serine/threonine-protein kinase VRK1; vaccinia virus B1R-related kinase 1; Vaccinia-related kinase 1
Gene Aliases: PCH1; PCH1A; VRK1
UniProt ID: (Human) Q99986
Entrez Gene ID: (Human) 7443