This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
The synthetic peptide sequence is 173-188aa, KMIDERQQELTHQEHR
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Metavinculin; RP11-178G16.3; vinc; Vinculin
Gene Aliases: 9430097D22; AA571387; AI462105; AW545629; Vcl
UniProt ID: (Mouse) Q64727
Entrez Gene ID: (Mouse) 22330