Immunogen sequence: YLDILAISCDS FDEEVNVLIG RGQGKKNHVE NLQKLRRWCR DYRVAFKINS VINRFNVEED MTEQIKALNP VRWKVFQCLL IEGENCGEDA L
Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2510004L01Rik; cig33; cig5; Cytomegalovirus-induced gene 5 protein; endoplasmic reticulum-associated; interferon-inducible; Radical S-adenosyl methionine domain-containing protein 2; RSAD2; vig1; Viperin; virus inhibitory protein; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Aliases: 2510004L01Rik; cig33; CIG5; RSAD2; vig1
UniProt ID: (Human) Q8WXG1
Entrez Gene ID: (Human) 91543