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Proteintech
WASF2 Polyclonal Antibody
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Product Details
31442-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WASF2 fusion protein Ag35663
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Amount
67.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KKDNPNRGNV NPRKIKTRKE EWEKMKMGQE FVESKEKLGT SGYPPTLVYQ NGSIGCVENV DASSYPPPPQ SDSASSPSPS FSEDNLPPPP AEFSYPVDNQ RGSGLAGPKR SSVVSPSHPP PAPPLGSPPG PKPG
Target Information
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin-binding protein WASF2; Protein WAVE-2; putative Wiskott-Aldrich syndrome protein family member 4; suppressor of cyclic-AMP receptor (WASP-family); unnamed protein product; Verprolin homology domain-containing protein 2; WAS protein family member 2; WASP family protein member 2; WASP family protein member 4; WASP family Verprolin-homologous protein 2; Wiskott-Aldrich syndrome protein family member 2
Gene Aliases: AW742646; D4Ertd13e; dJ393P12.2; IMD2; SCAR2; WASF2; WASF4; WAVE2
UniProt ID: (Human) Q9Y6W5, (Mouse) Q8BH43
Entrez Gene ID: (Human) 10163, (Mouse) 242687
angiogenesis
ameboidal-type cell migration
neuron migration
endocytosis
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
positive regulation of lamellipodium assembly
Rac protein signal transduction
lamellipodium assembly
actin cytoskeleton organization
actin filament-based movement
megakaryocyte development
cell motility
negative regulation of stress fiber assembly
lamellipodium morphogenesis
postsynaptic actin cytoskeleton organization
postsynapse organization
positive regulation of Arp2/3 complex-mediated actin nucleation
movement of cell or subcellular component
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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