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Fabgennix
WDR5 Polyclonal Antibody, FITC
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Product Details
WDR5-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide:DVKTGKCLKTLPAHSDPVcorresponding to amino acids 157-174 of Human WDR5 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP-2-induced gene 3 kb; BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3, Set1c WD40 repeat protein, homolog; unnamed protein product; WD repeat-containing protein 5; WD repeat-containing protein BIG-3
Gene Aliases: 2410008O07Rik; AA408785; AA960360; Big; BIG-3; BIG3; CFAP89; SWD3; WDR5
UniProt ID: (Human) P61964, (Mouse) P61965, (Rat) Q498M4
Entrez Gene ID: (Human) 11091, (Mouse) 140858, (Rat) 362093
protein binding
histone binding
histone methyltransferase activity (H3-K4 specific)
histone H3Q5ser reader activity
histone H3K4me1 reader activity
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
methylated histone binding
skeletal system development
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
neuron projection development
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
histone H3 acetylation
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
histone H3-K4 methylation
histone lysine methylation
negative regulation of transcription from RNA polymerase II promoter
gluconeogenesis
chromatin organization
regulation of transcription from RNA polymerase II promoter
positive regulation of gluconeogenesis
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
regulation of embryonic development
regulation of cell division
regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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