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Proteintech
WFS1 Polyclonal Antibody
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Product Details
26995-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WFS1 Fusion Protein Ag25724
Conjugate
Form
Liquid
Concentration
467 µg/mL
Amount
70.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: unnamed protein product; Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 (wolframin) isoform WFS1_1; Wolfram syndrome 1 (wolframin) isoform WFS1_2; Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; Wolframin
Gene Aliases: AI481085; CTRCT41; WFRS; WFS; WFS1; WFSL; wolframin
UniProt ID: (Human) O76024, (Mouse) P56695
Entrez Gene ID: (Human) 7466, (Mouse) 22393, (Rat) 83725
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
visual perception
sensory perception of sound
ER-associated ubiquitin-dependent protein catabolic process
endoplasmic reticulum unfolded protein response
positive regulation of protein ubiquitination
endoplasmic reticulum calcium ion homeostasis
response to endoplasmic reticulum stress
glucose homeostasis
negative regulation of programmed cell death
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
positive regulation of growth
protein stabilization
neurological system process
positive regulation of protein metabolic process
regulation of cell cycle
positive regulation of calcium ion transport
calcium ion homeostasis
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of ATF6-mediated unfolded protein response
negative regulation of type B pancreatic cell apoptotic process
ER overload response
regulation of gene expression
negative regulation of macromolecule biosynthetic process
negative regulation of translation
pancreas development
intracellular signal transduction
ERAD pathway
olfactory behavior
negative regulation of apoptotic process
negative regulation of intracellular signal transduction
negative regulation of response to endoplasmic reticulum stress
positive regulation of ERAD pathway
positive regulation of proteolysis
polyubiquitinated misfolded protein transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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