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WFS1 Polyclonal Antibody

View all (5) WFS1 antibodies

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WFS1 Polyclonal Antibody

Product Details

BS-11272R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human WFS1, amino acids 791-890.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

WFS1 is a novel component of Wolfram syndrome, a rare form of juvenile diabetes. WFS1 plays an important role in maintaining homeostasis of the endoplasmic reticulum (ER) in the pancreas. It is normally up-regulated during insulin secretion, whereas inactivation of the protein can cause ER stress. Chronic ER stress is a major involvement in Wolfram syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: unnamed protein product; Wolfram antibody; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 (wolframin) isoform WFS1_1; Wolfram syndrome 1 (wolframin) isoform WFS1_2; Wolfram syndrome 1 homolog; Wolfram syndrome 1 protein homolog; Wolframin

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Gene Aliases: AI481085; CTRCT41; WFRS; WFS; WFS1; WFSL; wolframin

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UniProt ID: (Human) O76024, (Mouse) P56695

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Entrez Gene ID: (Human) 7466, (Mouse) 22393, (Rat) 83725

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Function(s)
protein binding calmodulin binding ubiquitin protein ligase binding calcium-dependent protein binding ATPase binding proteasome binding DNA-binding transcription factor binding protein carrier chaperone activating transcription factor binding transporter activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development renal water homeostasis visual perception sensory perception of sound ER-associated ubiquitin-dependent protein catabolic process endoplasmic reticulum unfolded protein response positive regulation of protein ubiquitination endoplasmic reticulum calcium ion homeostasis response to endoplasmic reticulum stress glucose homeostasis negative regulation of programmed cell death negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron apoptotic process positive regulation of growth protein stabilization neurological system process positive regulation of protein metabolic process regulation of cell cycle positive regulation of calcium ion transport calcium ion homeostasis negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of ATF6-mediated unfolded protein response negative regulation of type B pancreatic cell apoptotic process ER overload response regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of translation pancreas development intracellular signal transduction ERAD pathway olfactory behavior negative regulation of apoptotic process negative regulation of intracellular signal transduction negative regulation of response to endoplasmic reticulum stress positive regulation of ERAD pathway positive regulation of proteolysis polyubiquitinated misfolded protein transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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