This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: LSLTREQMFA AQEMFKTANK VTRPEKALIL GFMAGSRENP CQEQGDVIQI KLSEHTEDLP KADGQGSTTM LVDTVFEMNY ATGQWTRFKK YKPMT
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ10442; FLJ25112; Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 protein
Gene Aliases: NELF-A; NELFA; P/OKcl.15; WHSC2
UniProt ID: (Human) Q9H3P2
Entrez Gene ID: (Human) 7469