This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: HQDRAFATAR LNFSGQRNIC TLSTIQKLPR LLVASSSGHL YMYNLDPQDG GECVLIKTHS LLGSGTTEEN KENDLRPSLP QSYAATVARP SASSASTVPG YSEDGGALRG EVIPEHEFAT GPVCLDDENE FPPIILCRG
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
WIPI1 (WD repeat domain, phosphoinositide interacting-1), also known as WIPI1, ATG18 or WIPI49, is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. It contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. WIPI1 localizes to cytoplasmic vesicles, endosomes, clathrin-coated vesicles and the trans-Golgi network. It is ubiquitously expressed with highest expression in heart, testis, placenta, pancreas and skeletal muscle. WIPI1 is upregulated in a variety of tumors, suggesting a role in carcinogenesis.
Protein Aliases: Atg18 protein homolog; WD repeat domain phosphoinositide-interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein Interacting with phosphoInositides of 49kDa; WIPI 49 kDa; WIPI-1; WIPI-1 alpha
Gene Aliases: 4930533H01Rik; ATG18; ATG18A; AW411817; D11Ertd498e; RGD1307754; WIPI1; WIPI49