This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Positive Control: K562, THP-1, Jurkat
Predicted Reactivity: Mouse (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
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Protein Aliases: WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI49-like protein 2
Gene Aliases: ATG18B; Atg21; CGI-50; WIPI-2; WIPI2