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Proteintech
WNK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
28357-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WNK1 Fusion Protein Ag28034
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
367 µg/mL
Amount
55.05 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: erythrocyte 65 kDa protein; KIAA0344; MGC163339; MGC163341; prostate-derived sterile 20-like kinase; protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K
Gene Aliases: HSAN2; HSN2; KDP; p65; PPP1R167; PRKWNK1; PSK
UniProt ID: (Human) Q9H4A3
Entrez Gene ID: (Human) 65125
regulation of sodium ion transport
protein phosphorylation
ion transport
cell volume homeostasis
cellular response to DNA damage stimulus
signal transduction
heart development
regulation of blood pressure
negative regulation of autophagy
negative regulation of sodium ion transport
regulation of mRNA export from nucleus
positive regulation of T cell chemotaxis
negative regulation of protein ubiquitination
negative regulation of cell-cell adhesion mediated by integrin
negative regulation of heterotypic cell-cell adhesion
intracellular signal transduction
sodium ion transmembrane transport
chemokine (C-C motif) ligand 21 signaling pathway
homeostatic process
protein insertion into ER membrane by stop-transfer membrane-anchor sequence
positive regulation of angiogenesis
neuron development
T cell receptor signaling pathway
negative regulation of small GTPase mediated signal transduction
potassium ion homeostasis
cation homeostasis
cellular hyperosmotic response
positive regulation of canonical Wnt signaling pathway
lymphocyte migration into lymph node
membraneless organelle assembly
regulation of sodium ion transmembrane transport
negative regulation of intracellular signal transduction
negative regulation of leukocyte cell-cell adhesion
negative regulation of protein localization to plasma membrane
positive regulation of mitotic cytokinesis
regulation of cation transmembrane transport
positive regulation of termination of RNA polymerase II transcription
cellular response to chemokine
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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