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Proteintech
WNK3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
32231-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WNK3 fusion protein Ag37713
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
450 µg/mL
Amount
67.5 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: AGCLEERRDS QCKSMGNVFP QPQNTTLPLA PAQQTGAECE ETEVDQHVRQ QLLQRKPQQH CSSVTGDNLS EAGAASVIHS DTSSQPSVAY SSNQTMGSQM VSNIPQAEVN VPGQIYSSQQ LVGHYQQVSG LQKHSKLTQP QILPLVQGQS T
Target Information
WNK3 is a serine/threonine kinase involved in signal transduction and cellular communication. Members of the 'with no lysine' kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prieto X-linked mental retardation syndrome; PRKWNK 3; protein kinase with no lysine 3; WNK 3
Gene Aliases: MRXS2; PRKWNK3; PRS
UniProt ID: (Human) Q9BYP7
Entrez Gene ID: (Human) 65267
protein phosphorylation
cell volume homeostasis
cellular response to DNA damage stimulus
osmosensory signaling pathway
positive regulation of sodium ion transport
positive regulation of peptidyl-threonine phosphorylation
intracellular signal transduction
maintenance of blood-brain barrier
negative regulation of apoptotic process
ion homeostasis
positive regulation of calcium ion transport
renal sodium ion absorption
cellular hyperosmotic response
protein localization to plasma membrane
negative regulation of pancreatic juice secretion
positive regulation of canonical Wnt signaling pathway
regulation of calcium ion import
membraneless organelle assembly
negative regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
regulation of cation transmembrane transport
positive regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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