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Product Details
22326-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WNK4 Fusion Protein Ag17773 (845-1243 aa encoded by BC136664)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PISSQVSSN PSPHPTSSPL PFSSSTPEFP VPLSQCPWSS LPTTSPPTFS PTCSQVTLSS PFFPPCPSTS SFPSTTAAPL LSLASAFSLA VMTVAQSLLS PSPGLLSQSP PAPPSPLPSL PLPPPVAPGG QESPSPHTAE VESEASPPPA RPLPGEARLA PISEEGKPQL VGRFQVTSSK EPAEPLPLQP TSPTLSGSPK PSTPQLTSES SDTEDSAGGG PETREALAES DRAAEGLGAG VEEEGDDGKE PQVGGSPQPL SHPSPVWMNY SYSSLCLSSE ESESSGEDEE FWAELQSLRQ KHLSEVETLQ TLQKKEIEDL YSRLGKQPPP GIVAPAAMLS SRQRRLSKGS FPTSRRNSLQ RSEPPGPGIM RRNSLSGSST GSQEQRASKG VTFAGDVGRM (845-1243 aa encoded by BC136664)
Target Information
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4
Gene Aliases: 2010002J11Rik; PHA2B; PRKWNK4; WNK4
UniProt ID: (Human) Q96J92, (Mouse) Q80UE6
Entrez Gene ID: (Human) 65266, (Mouse) 69847
protein phosphorylation
ion transport
chloride transport
protein localization
positive regulation of ion transmembrane transporter activity
intracellular signal transduction
regulation of cellular process
ion homeostasis
renal sodium ion absorption
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
regulation of ion homeostasis
phosphorylation
cellular chloride ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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