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Proteintech
WNK4 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
22326-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WNK4 Fusion Protein Ag17773 (845-1243 aa encoded by BC136664)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PISSQVSSN PSPHPTSSPL PFSSSTPEFP VPLSQCPWSS LPTTSPPTFS PTCSQVTLSS PFFPPCPSTS SFPSTTAAPL LSLASAFSLA VMTVAQSLLS PSPGLLSQSP PAPPSPLPSL PLPPPVAPGG QESPSPHTAE VESEASPPPA RPLPGEARLA PISEEGKPQL VGRFQVTSSK EPAEPLPLQP TSPTLSGSPK PSTPQLTSES SDTEDSAGGG PETREALAES DRAAEGLGAG VEEEGDDGKE PQVGGSPQPL SHPSPVWMNY SYSSLCLSSE ESESSGEDEE FWAELQSLRQ KHLSEVETLQ TLQKKEIEDL YSRLGKQPPP GIVAPAAMLS SRQRRLSKGS FPTSRRNSLQ RSEPPGPGIM RRNSLSGSST GSQEQRASKG VTFAGDVGRM (845-1243 aa encoded by BC136664)
Target Information
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: protein kinase; protein kinase lysine-deficient 4; protein kinase with no lysine 4; protein kinase, lysine deficient 4; RP23-281C18.8; unnamed protein product
Gene Aliases: 2010002J11Rik; PHA2B; PRKWNK4
UniProt ID: (Human) Q96J92, (Mouse) Q80UE6
Entrez Gene ID: (Human) 65266, (Mouse) 69847
response to dietary excess
renal sodium ion transport
protein phosphorylation
inflammatory response
signal transduction
regulation of blood pressure
response to xenobiotic stimulus
gene expression
negative regulation of sodium ion transport
cellular chloride ion homeostasis
intracellular signal transduction
sodium ion transmembrane transport
aldosterone secretion
macrophage activation
homeostatic process
ion homeostasis
calcium ion homeostasis
renal sodium ion absorption
ERK1 and ERK2 cascade
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
distal tubule morphogenesis
negative regulation of protein localization to plasma membrane
regulation of potassium ion export across plasma membrane
response to aldosterone
negative regulation of protein kinase activity
chloride transport
protein localization
regulation of metal ion transport
activation of protein kinase activity
regulation of protein kinase activity
negative regulation of pancreatic juice secretion
positive regulation of potassium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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