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Bioss
WNK4 Polyclonal Antibody
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Product Details
BS-0429R
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human WNK4, amino acids 351-450.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; protein kinase, lysine deficient 4; protein kinase, lysine-deficient 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4; unnamed protein product; WNK4 Ser/Thr kinase
Gene Aliases: 2010002J11Rik; Ac2-059; PHA2B; PRKWNK4; WNK4
UniProt ID: (Human) Q96J92, (Mouse) Q80UE6, (Rat) Q7TPK6
Entrez Gene ID: (Human) 65266, (Mouse) 69847, (Rat) 287715
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
ion channel inhibitor activity
kinase activity
transferase activity
chloride ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
chloride channel inhibitor activity
non-receptor serine/threonine protein kinase
response to dietary excess
renal sodium ion transport
protein phosphorylation
chloride transport
inflammatory response
signal transduction
protein localization
regulation of blood pressure
response to xenobiotic stimulus
gene expression
negative regulation of sodium ion transport
cellular chloride ion homeostasis
intracellular signal transduction
sodium ion transmembrane transport
aldosterone secretion
macrophage activation
homeostatic process
ion homeostasis
calcium ion homeostasis
renal sodium ion absorption
ERK1 and ERK2 cascade
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
negative regulation of protein localization to plasma membrane
regulation of potassium ion export across plasma membrane
ion transport
phosphorylation
regulation of cellular process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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