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Product Details
PA5-34707
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 253 of XRCC2 (Uniprot ID#O43543)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2552059
Product Specific Information
Recommended positive controls: Molt-4, Raji.
Predicted reactivity: Rat (81%), Bovine (85%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781P0919; DNA repair protein XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross-complementing protein 2
Gene Aliases: FANCU; XRCC2
UniProt ID: (Human) O43543
Entrez Gene ID: (Human) 7516
mitotic cell cycle
meiotic DNA recombinase assembly
double-strand break repair via homologous recombination
DNA synthesis involved in DNA repair
strand displacement
in utero embryonic development
somitogenesis
DNA repair
mitotic recombination
meiotic nuclear division
reciprocal meiotic recombination
response to X-ray
response to ionizing radiation
response to gamma radiation
multicellular organism growth
strand invasion
negative regulation of neuron apoptotic process
positive regulation of neurogenesis
centrosome organization
regulation of fibroblast apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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