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Proteintech
YTHDF2 Polyclonal Antibody, CoraLite® Plus 488
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FIGURE: 1 / 1
YTHDF2 Antibody (CL48824744100UL) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite 488 Anti-Human YTHDF2 (Product # CL48824744100UL)) (red), or 0.4 µg Control Antibody. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL48824744100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 9430020E02Rik; CLL-associated antigen KW-14; DF2; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2; unnamed protein product; YTH domain family 2; YTH domain family protein 2; YTH domain family, member 2; YTH domain-containing family protein 2; YTH N(6)-methyladenosine RNA binding protein 2; YTH N6-methyladenosine RNA binding protein 2
Gene Aliases: 9430020E02Rik; CAHL; DF2; HGRG8; NY-REN-2; YTHDF2
UniProt ID: (Human) Q9Y5A9, (Mouse) Q91YT7
Entrez Gene ID: (Human) 51441, (Mouse) 213541, (Rat) 313053
oocyte maturation
immune system process
mRNA catabolic process
humoral immune response
gamete generation
spermatogenesis
spermatogonial cell division
cell differentiation
regulation of cell adhesion
stress granule assembly
regulation of mRNA stability
innate immune response
negative regulation of Notch signaling pathway
positive regulation of translational initiation
oogenesis
embryonic morphogenesis
regulation of neurogenesis
cell division
negative regulation of type I interferon-mediated signaling pathway
mRNA destabilization
organelle assembly
hematopoietic stem cell proliferation
endothelial to hematopoietic transition
regulation of hematopoietic stem cell differentiation
regulation of meiotic cell cycle process involved in oocyte maturation
positive regulation of cap-independent translational initiation
regulation of rRNA processing
negative regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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