Immunogen sequence: RNRGSGFGHNG VDGNGVGQSQ AGSGSTPSEP HPVLEKLRSI NNY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation. Also acts as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 9430020E02Rik; CLL-associated antigen KW-14; HGRG8; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2; YTH domain family, member 2; YTH domain-containing family protein 2; YTH N(6)-methyladenosine RNA binding protein 2
Gene Aliases: CAHL; HGRG8; NY-REN-2; YTHDF2
UniProt ID: (Human) Q9Y5A9
Entrez Gene ID: (Human) 51441