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Invitrogen
ZBP1 Polyclonal Antibody
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Product Details
PA5-20455
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive controls are mouse small intestine or human small intestine tissue lysate.
PA5-20455 can be used with blocking peptide PEP-0572.
PA5-20455 detects ZBP1 in WB application with human samples.
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAI; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; unnamed protein product; Z-DNA-binding protein 1
Gene Aliases: 2010010H03Rik; C20orf183; DAI; DLM-1; DLM1; mZaDLM; ZBP1
UniProt ID: (Human) Q9H171, (Mouse) Q9QY24
Entrez Gene ID: (Human) 81030, (Mouse) 58203, (Rat) 171091
activation of innate immune response
immune system process
apoptotic process
programmed cell death
positive regulation of apoptotic process
innate immune response
regulation of inflammatory response
positive regulation of inflammatory response
defense response to fungus
defense response to virus
positive regulation of type I interferon-mediated signaling pathway
positive regulation of necroptotic process
pyroptosis
necroptotic signaling pathway
execution phase of necroptosis
antiviral innate immune response
regulation of interleukin-1-mediated signaling pathway
viral process
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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